megaloblastic anaemia การใช้

megaloblastic anaemia and nerve damage . during pregnancy and lactation respectively.
Mutations in these genes may cause a decrease in the uptake of vitamin B12 leading to megaloblastic anaemia.
As FANCA is also linked to cell-cycling and its progression from G2 phase, the stage impaired in megaloblastic anaemia, its expression in definitive proerythroblast development may be an upstream determinant of erythroid size.
As FANCA is heavily implicated in controlling cellular proliferation, and often results in patients developing megaloblastic anaemia around age 7, a haematological disorder marked physically by proliferation-impaired, oversized erythrocytes, it is possible that the size and proliferative discrepancies between primitive, foetal and adult erythroid lineages may be explained by FANCA expression.
Another major effect is the loss of the anaemia known as megaloblastic anaemia ( can also be caused by folate deficiency, or autoimmune disease where it is specifically known as pernicious anaemia ) which severely reduces red-blood cell synthesis ( known as erythropoiesis, as well as other haemotological cell lineages if severe enough but the red cell is the first to be affected ).